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human cells

PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy

Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response (UPR)

human cells

egg cells flowing in a blue background

Authors:
Salaroglio, IC; Panada, E; Moiso, E; Buondonno, I; Provero, P; Rubinstein, M; Kopecka, J; Riganti, C

Abstract:
Nutrient deprivation, hypoxia, radiotherapy and chemotherapy induce endoplasmic reticulum (ER) stress, which activates the so-called unfolded protein response (UPR). Extensive and acute ER stress directs the UPR towards activation of death-triggering pathways. Cancer cells are selected to resist mild and prolonged ER stress by activating pro-survival UPR. We recently found that drug-resistant tumor cells are simultaneously resistant to ER stress-triggered cell death. It is not known if cancer cells adapted to ER stressing conditions acquire a chemoresistant phenotype.

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