Share icon Three circles with dashes Person icon Man with pen You Tube Logo Just "You tube" text Facebook logo Small letter f Search icon Magnifier Twitter logo Simplified small bird Email icon Envelope
Skip to main
Cattle and humans share a tool for digesting tough material. image: Wikimedia commons

Scottish-Israeli Collaboration Finds Cow Bacterial Tool in Human Gut

A long collaboration between Israeli and UK researchers is finding the cellulosome - a bacterium's tool for digesting tough plant fibers - in odd places

Cattle and humans share a tool for digesting tough material. image: Wikimedia commons

Cattle and humans share a tool for digesting tough material. image: Wikimedia commons

 

“The new discovery,” says Bayer, “actually started with the cow.” Bayer had met Prof. Harry Flint of the University of Aberdeen, UK, at a conference where Flint described a component of the cow-rumen bacterium he was studying. Bayer recognized in the description the components of a cellulosome. But Flint’s picture of the cow’s cellulosome was incomplete, and thus began a long collaboration with Bayer’s lab to study the structure and function of this machinery in an animal’s digestive system.

The bacteria in a cow’s rumen are the main agents of digestion, breaking down into shorter bits the cellulose and other long polysaccharide molecules in hay and grass. The group’s research showed that the cellulosomes on these bacteria are built on the same basic plan as those in the wood-eating bacteria, with attachable enzymes that are adapted to breaking down the cellulose in the grasses.

Prof. Ed Bayer
Prof. Ed Bayer

 

We humans, of course, digest most of our food without the aid of bacteria, but a body of research in recent years shows that we, too, rely on the activities of the populations of bacteria in our intestinal tracts – our microbiomes. Our microbiomes have now been found to affect everything from our weight to our metabolic and immune system functions. With the flood of new research describing the genetics of microbiome populations, Bayer and his colleagues managed to find cellulosomes in bacteria that live in the human small intestine. It was a French team that published the genome of a human intestinal bacterium that appeared to be similar to the cow bacterium and in which, says Bayer, “we smelled cellulosome-like elements.”

Bayer, senior intern Dr. Sarah Moraïs, postdoctoral fellow Bareket Dassa and research student Yonit Ben David, together with Flint, Lamed and Ilya Borovok; as well as Nicole M. Koropatkin and Eric C. Martens of University of Michigan Medical School, and Annick Bernalier-Donadille, head of the French group at INRA, France, went to work on the genetic sequence of this bacterium. At first, their results were inconclusive. There were some cellulosome components in the bacterial genome, but there appeared to be too few to make a complete cellulose-eating machine. On closer inspection, however, the team found that several segments of the genome had been overlooked in their search. When Moraïs carefully sequenced the missing segments, the verdict was in: These particular human gut bacteria carry cellulosomes.

Since we don’t normally live off grass or hay, why do we have these bacteria?

In parallel research, Bayer and his colleagues found yet another new cellulosome-bearing bacterium in the human microbiome.  This one, rather than digesting cellulose, is tailored to breaking down indigestible starch molecules.

These cellulosomes as well as the bacteria that carry them are very closely related to their cow counterparts. Since we don’t normally live off grass or hay, why do we have these bacteria? Bayer thinks they may have a protective function – preventing damage to the soft tissue of our digestive tract from the abrasive cellulose fibers we ingest in our fruit and vegetables. But the bacteria are also part of a class of intestinal bacteria that are thought to affect our metabolism, including our tendency to obesity, metabolic syndrome and diabetes. So the findings point to further avenues of research, and they suggest that the cellulosome may indeed be crucial to our health and well-being.

This article originally appeared on the Weizmann Wonder Wander under the title: Me and My Cellulosome

____________________________________________________________________________________________________________________________

Israel BDS – building dialogue through science – aims to promote the kind of international collaboration that can lead to true understanding between people. Israel BDS stands for the free and open exchange of ideas among scientists everywhere. By reporting on the benefits of Israeli-international scientific research and the web of connections that these scientists create around the world, Israel BDS takes a vibrant approach to highlighting the global necessity of continued international scientific collaboration.

___________________________________________________________________________________________________________________________